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What is Cannabidiol Monomethylether (CBD-M)?

Cannabidiol monomethylether (CBDM) is one of the compounds found in Marijuana or Cannabis. Cannabis is a genus belonging to the family of Cannabaceae. Differing species of plants found within the Cannabis genus can be highly variable.

Over the years, especially in the mid-seventies, the quest to find new natural cannabinoids that were as a result of isolation from the Cannabis sativa preparation with other sub-species and varieties led to the discovery of Cannabidiol (CBD). Alongside  (–)- trans-Δ –tetrahydrocannabinol (Δ –THC), these are the most abundant chemical compounds in the Cannabis plant.

These two have been subsequently considered as the most relevant curative components of the plant thereby making Cannabidiol Monomethylether (CBDM) a promising curative component too. Studies however have revealed that it might be difficult to classify cannabidiol monomethylether as either a natural or synthetic cannabidnoidic derivative of CBD.

Nonetheless, evidence shows that the compound must have existed in natural form. However, the fact that CBDM exists in such minute quantities in the Cannabis plant makes it impossible for the compound to be isolated in the first attempt. This makes the commercialization and business management end of possible products more difficult.

After considering the present studies and multiple examinations, it has been concluded that CBDM is a natural component of the cannabis plant. There have been some tests attempting to isolate Cannabidiol Monomethyl Ether as a new minor cannabinoid. These tests came from the ‘Minamioshihara No. 1’ – domestic hemp species.

Since CBDM is a derivative of CBD and so little is known about it, much of the speculation about the compound is linked to the properties of Cannabidiol.

Cannabidiol was isolated in 1940 (Adams et al., 1940) and its absolute configuration established by synthesis of ()-CBD as ()-trans-(1R,6R)(Petrzilka et al., 1969). The optical rotation of cannabidivarin was reported as [a]D 139.5(chloroform) (Vollner et al., 1969).

All of the known CBD-type cannabinoids have trans-(1R,6R) absolute configuration and presumably also negative optical rotation.


Oxidative metabolism of cannabidiol CBDM, one of the components of marijuana, was studied in guinea pigs. CBDM was found to be formed with hepatic microsomes by gas chromatography-mass spectrometry (GC-MS).

Experiments using various modifiers of enzymatic reactions suggested that, as in the case of cannabielsoin (CBE) formation from CBD, CBD monomethylether (CBDM) was formed from the monooxygenase system including cytochrome P450.

When cannabidiol dimethyl ether (CBDD), in which phenolic hydroxyl groups of CBD are masked with methyl groups, was incubated with liver microsomes and a reduced nicotinamide adenine dinucleotide phosphate-generating system, 1S, 2R-epoxy-CBDD was identified by GC-MS .


As with every cannabinoid, there is always a unique pharmacological effect and in this, CBDM is no exception. Any potential edible products should be produced by a certified food protection professional. As a derivative of Cannabidiol, it can also serve, among many others, as:

An anti-epileptic medicine

  • Cannabidiol monomethylether has tendencies to prevent and serve as a cure for epilepsy though further research is ongoing concerning this.

An anti-inflammatory remedy

  • Cannabidiol monomethylether just like many other cannabinoids can work effectively to reduce inflammation/swelling.

An aid to mobility

  • Cannabidiol monomethylether has the medical benefit of aiding movement. This implies it has the capacity of interacting with bones and every hormone responsible for movement to bring about the best result.


Cannabidiol monomethylether can serve as a curative for memory-related issues. Always consult your primary care provider before supplementing or beginning a new medication. Additionally, and I can’t stress this enough, only purchase edible CBD products from reputable sources under the watch of a certified food protection professional.

Any reputable company will keep current on its certified exam maintaining credentials as well.

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Adams, R., Hunt, M., Clark, J.H., 1940. Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. I. Journal of the American Chemical Society 62, 196–200.

Petrzilka, T., Haefliger, W., Sikemeier, C., 1969. Synthesis of hashish components. IV. Helvetica Chimica Acta 52 (4), 1102–1134.

Vollner, L., Bieniek, D., Korte, F., 1969. Hashish. Cannabidivarin, a new hashish component. Tetrahedron Letters 3, 145–147.

About the Author

Dale Hewett Author

Dale Hewett

Dale is the owner and founder of New Phase Blends. He discovered his passion for CBD use after suffering from injuries sustained while on Active Duty in the US Army. His number one priority is introducing the same CBD products that he himself uses for relief to others who can benefit from them.

Dale holds a Master Degree of Science, and is the inventor of the popular, patent-pending CBD-based sleep aid known as ‘Sleep.’