WHAT IS CANABIDIORCOL (CBD-C1)?

Cannabidiorcol (CBD-C1) is a type of Cannabidiol (CBD). This family of cannabinoidscontains several other compounds, namely Cannabidiol – C1 (CBD-C1), Cannabidiol – C4 (CBD-C4)  and Cannabidiolic Acid (CBDA).

Cannabidiorcol is also known as Cannabidiorocol – O 1821 – Cannabidiorcol. Its Chemical formula is written as C17H22O2, having a molecular weight of 258 and LogP of 4.4 with the density being 1.073g/cm3. Its boiling point is 401.6C at 760 mmHg.

There are two types of Cannabidiol, natural and synthetic. The natural form of CBD is derived from plants, while synthetic CBD is formed in a laboratory through the process of synthesiation.

Of the over 120 natural cannabinoids identified in Cannabis plant, seven have been classified as CBD-type compounds. All of them have the same absolute configuration of CBD; they are 5′-methyl-2′-(prop-1-en-2-yl)-1′,2′,3′,4′-tetrahydro-[1,1′-biphenyl]-2,6-dioles retaining the trans-(1 R,6 R) configuration.

Synthetic cbd formulations are chemical analogues of the above compounds.

Cannabidiolic acid (CBDA) and cannabidivarinic acid (CBDVA-C3) are C3′-carboxylic derivatives, whereas cannabidiorcol (CBD-C1), cannabidiol-C4 also named as nor -cannabidiol (CBD-C4), and cannabidivarin (CBDV) differ from CBD by the length of their C4′-side chain. Cannabidiol monomethyl ether (CBDM), the C6′-methoxy CBD analog, was also isolated from the plant.

Despite the potential therapeutic interest of these naturally occurring CBD derivatives, only a few related pharmacological studies have been reported.

The first discovery of an individual cannabinoid was made when British chemist Robert S. Cahn identified the partial structure of Cannabinol (CBN), which he later discovered as fully formed in 1940. Two years later, American chemist Roger Adams made history when he successfully isolated the first cannabinoid, Cannabidiol. His research is also responsible for the discovery of Tetrahydrocannabinol (THC).

Cannabidiorcol is one of the naturally occurring derivatives of CBD. It  has much therapeutic interest but despite the interest, there exist only a handful of pharmacological studies on it.

This current lack of study does not mean it won’t gain attention in the future.

HOW IT WORKS

Members of the CBD class of cannabinoids bind weakly to CB1 receptors and act as an “inverse agonist” at the CB2 receptors (Ligresti, et al, 2016).

A molecule that combines with a receptor on a cell to produce a physiological reaction is referred to as an agonist. An inverse agonist, then, is an agent that aids the combination with the receptor to bring about a counter response to what would have occurred naturally.

This explains part of the impact of CBD in the human body system when it binds to cannabinoid receptors. One such impact is a moderation of THC effects.

THERAPEUTIC BENEFITS

Generally, Cannabidiols can act as anti-depressant, anti-anxiety, anti-inflammatory and antipsychotic agents. This can be said of CBD-C1 since it belongs to the family too. CBD-C4 is capable of acting as an anti-nausea and antioxidant agent.

INTERESTING FACTS

Since CBD-C1 is a class of Cannabidiols, it does not have intoxicating and psychoactive abilities and can be used for neurodevelopmental diseases.

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References

Aizpurua-Olaizola O., Soydaner U., Öztürk E., Schibano D., Simsir Y., Navarro P., et al. (2016). Evolution of the cannabinoid and terpene content during the growth of cannabis sativa plants from different chemotypes. J. Nat. Prod. 79 324–331. 10.1021/acs.jnatprod.5b0094.

ElSohly M. A., Gul W. (2014). “Constituents of cannabis sativa,” in Handbook of Cannabis , ed. Pertwee R. G. (Oxford: Oxford University Press; ), 3–22. 10.1093/acprof [CrossRef] [Google Scholar]

ElSohly M. A., Slade D. (2005). Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci. 78 539–548. 10.1016/j.lfs.2005.09.011 [ PubMed] [ CrossRef] [ Google Scholar ]

Ligresti A, De Petrocellis L, Di Marzo V. From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology. Physiological reviews. 2016 Oct;96(4):1593-659.

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