Free Shipping Within the US
Money Back Guarantee

CANNABIDIOLIC ACID (CBDA)

Dale blog imageAuthor: Dale Hewett
cannabidiolic acid CBDA featured
Table of Contents (Scrollable)

WHAT IS CANNABIDIOLIC ACID (CBDA)?

With the consistent drive by researchers to discover more about Cannabidiol (CBD), and other cannabinoids that exist within the cannabis plant, new compounds are being discovered. Each one contains its unique properties and potential medicinal uses. One of these discovered cannabinoids is Cannabidiolic acid (CBDA).

CBDA is one of several other acidic cannabinoids produced by cannabis plants that’s recently been discovered by scientists.

It is a derivative of CBD.

Related article: The Differences Between CBDA and CBD

Remember, both hemp and marijuana make up the cannabis plant family.

Cannabis Species Chart

CBDA was first recognized in 2008 via a study that was done by the American Society for Pharmacology and Experimental Therapeutics Journal (ASPET). It was discovered by ASPET that CBDA is a non-psychoactive cannabinoid, unlike its other counterpart THC. It was also discovered that CBDA has the same anti-inflammatory benefits as CBD.

Cbd Vs Cbda Molecules

Since its’ discovery, a series of studies have been ongoing to create a concrete foundation of understanding the cannabis plant and the cannabinoids within the cannabis plant.

Some of these studies report that the compound shows huge potential in treating inflammation, anxiety, aches, and also in improving mood.

Discover: CBD Gummies for Anxiety

A recent study conducted by Orgeon State University concluded that CBDA, and CBGA (another acidic cannabis compound) may actually prevent the spread of the COVID 19 virus in human cells.

Unfortunately, a lot of these studies are done with major cannabinoids like CBD, THC, or even CBN. Their derivatives lack comprehensive studies, so it makes it very difficult to give concrete evidence in regards to their therapeutic effects or uses.

Creating the Cannabinoid Known As CBDA

While the first compound that is formed in the plant is CBDA, when heated, it loses its acidic carboxyl group and then converts to CBD – the process whereby the acidic carboxyl group is lost is known as decarboxylation.

More simply put, CBDA is converted to CBD when exposed to forms of heat. This is how major cannabinoid precursor compounds are converted into compounds that will bind to endocannabinoid receptors.

Related: CBD vs CBN

This heating process can occur either naturally when the plant is left to slowly degrade over time, or with the intervention of humans when the cannabis plant is smoked or exposed to other methods of extreme heat.

How Does CBDA Affect The Body?

We have what are known as CB receptors in our brain that are made to bind directly with psychoactive cannabinoids that are found in cannabis plants, like THC. These receptors make up what is known as the endocannabinoid system.

CBDA does not work in the same way as THC does with this bodily system.

Cbd Brain Diagram

THC has a very strong binding affinity for CB receptors, which is why it products the high effect that so many people have heard of. CBDA interacts with the endocannabinoid system by inhibiting the Cox-2 enzyme, which does not directly affect the central nervous system.

CBD, and derivatives of CBD, are thought to bind very weakly to their receptor locations. There are even some scientists who believe CBD binds with other receptors that have not been discovered yet.

POSSIBLE THERAPEUTIC BENEFITS

Interestingly enough, CBDA may have a stronger activation of 5-HT1A receptors for seratonin, when compared to its’ parent molecule CBD. Serotonin regulates many different things for us, including our moods, feelings of nausea, vomiting, and intestinal regulation.

Even though potential CBDA benefits have been shown in numerous therapeutic studies, it is yet to be an acceptable clinical means of treatment. Being an unstable compound, research is still going on to see how it can be stable, and how it can become a viable option for clinical use.

Here are some of the therapeutic benefits of CBDA:

Prevention of COVID 19 Virus

Oregon State University released a ground breaking study in January of 2022.

In a study headed by Richard van Breemen, findings specify that CBDA (in addition to CBGA) can prevent the virus that in responsible for COVID-19 from entering human cells.

For Nausea and vomiting

In a study that was done on mice and rats, it was reported that CBDA was able to reduce anticipatory nausea and vomiting. It was said to be more potent at controlling nausea than CBD. Raw cannabis juice works well here.

For Depression and anxiety

There is a serious discussion surrounding the ability of CBD to reduce anxiety. Likewise, studies were done using rats to determine the effectiveness of CBDA against anxiety and depression. It was recorded that rats pre-treated with CBDA did not exhibit any form of anxiety in response to the test carried out on them.

Discover: Using CBD for Stress

For Breast Cancer

A 2012 study showed that CBDA was able to stop the migration and invasion of deadly human breast cancer cells. Another study also showed that CBDA was able to suppress genes that are associated with breast cancer.

INTERESTING FACTS

  • CBDA acid becomes CBD. It is then heated in a process called decarboxylation to form CBD. The conversion of THCA to THC works the same way.
  • It has been shown by scientists that CBDA has 100 times the binding affinity for certain receptors when compared to CBD from raw cannabis.

Cbd Products Online Discount Banner

REFERENCES

Citti C, Pacchetti B, Vandelli MA, Forni F, Cannazza G. Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA). J Pharm Biomed Anal. 2018 Feb 5;149:532-540. doi: 10.1016/j.jpba.2017.11.044. Epub 2017 Nov 20. PMID: 29182999.

Bolognini, D., Rock, E., Cluny, N., Cascio, M., Limebeer, C., Duncan, M., … Pertwee, R. (2013). Cannabidiolic acid prevents vomiting inSuncus murinusand nausea-induced behaviour in rats by enhancing 5-HT1Areceptor activation. British Journal of Pharmacology, 168(6), 1456–1470.

Rock EM, Limebeer CL, Petrie GN, Williams LA, Mechoulam R, Parker LA. Effect of prior foot shock stress and delta-9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats. Psychopharmacology (Berl). 2017;234(14):2207-2217. doi:10.1007/s00213-017-4626-5

Takeda, S., Okajima, S., Miyoshi, H., Yoshida, K., Okamoto, Y., Okada, T., … Aramaki, H. (2012). Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicology Letters, 214(3), 314–319.

Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoidsBr J Pharmacol. 2011;163(7):1411-1422. doi:10.1111/j.1476-5381.2010.01176.x

Van Breemen RB, Muchiri RN, Bates TA, Weinstein JB, Leier HC, Farley S, Tafesse FG. Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants. J Nat Prod. 2022 Jan 10. doi: 10.1021/acs.jnatprod.1c00946. Epub ahead of print. PMID: 35007072.

 

blog BG
Table of Contents
Buy CBD Now

Recent Posts

Commitment to Trusted Information on CBD

When it comes to understanding both the science and benefits of cannabidiol (CBD), it is extremely important that you can trust the source of your information. This is exactly why our team at New Phase Blends includes experts in the field of cannabinoid research and development, including frequent correspondence with certified medical professionals and PhDs in relevant fields via studies, research, and additional peer reviewed pieces of information. We pride ourselves on staying up-to-date with the latest scientific research and clinical studies related to not only CBD, but also its effects on the human body.

Our website also includes an About Us page, where you can learn more about our team, mission, and commitment to providing accurate, reliable information about CBD. Additionally, all of our products are third-party lab tested for quality and purity, and we make the results of these tests easily accessible to our customers.

We understand that choosing a CBD product can be a daunting task, especially with so much conflicting information available online. That’s why we strive to be a one-stop-shop for all your CBD education and product needs. From beginner’s guides to detailed explanations of different types of CBD products, we provide comprehensive information to help you make informed decisions about incorporating CBD into your wellness routine.

We hope you find our website to be a valuable resource in your journey to learn about CBD and its potential benefits. If you have any questions or concerns, please don’t hesitate to reach out to our customer service team, who are always happy to help.

User Experience Strengthened Through The Use of AI Content

Some articles you read may contain content created by the use of AI tools. This content is always edited by a human. We fact check any AI content, and ensure the information produced is accurate, up to date, and relevant to the article it may be contained in. All content is verified against peer reviewed data on CBD written by PhD’s and respective experts in their field of medical science.

Our goal in using AI content is to increase the user experience by increasing content production, and quality. This results in more information becoming available to the reader more frequently.

About the Author - CBD Expert Dale Hewett

Dale Hewett is the owner and founder of New Phase Blends. He discovered his passion for CBD use after suffering from injuries sustained while on Active Duty in the US Army. His number one priority is introducing the same CBD products that he himself uses for relief to others who can benefit from them.

Dale holds a Master Degree of Science, and is the inventor of the popular, CBD-based sleep aid known as ‘Sleep.’ He’s given multiple lectures on CBD to institutions such as Cornell’s MBA student program, and Wharton’s School of Business.

la wire logo
yahoo finance greyscale
forbes logo
Markets Insider Logo
chicago journal logo greyscale

Visit the Best CBD Blog Online

Visit the best CBD blog online to read more articles like the one above. New Phase Blends is home to the most comprehensive data on CBD you’ll find.