While there are side effects of CBD oil, they are really not bad at all when compared to other medications. While CBD and other phytocannabinoids are an ancient product people have used for thousands of years, it was just legalized in the United States via the Farm Bill of 2018. For this reason, a lot of real peer reviewed research is lacking when compared to other products that treat similar symptoms like advil or or tylenol. Don’t worry though! Side effects of CBD oil have been studied, just not to the degree of other major OTC or pharmaceutical medications.
Known Side Effects of CBD Oil
As a rule of thumb, its very important to get all information on the side effects of CBD oil from proper, peer reviewed scientific journals or publications. If you simply follow headlines or news or clickbait headlines, you may, or may not, get accurate information. For this reason, I will discuss the KNOWN side effects, and post links as references below so you can be 100% sure this information is from peer reviewed sources.
According to Cannabis and Cannabinoid Research publications “the most common [negative] side effects of cbd oil were changes in weight, tiredness, and diarrhea.” This particular study came from an extensive research panel on 132 different studies ranging from CBD oil usage for up to 1500mg per day. Keep in mind, 1500mg of CBD is a VERY high amount, and most certainly would give side effects. To put this into perspective, our most popular product (CBD oil for Sleep) has a total of 2000mg of rich CBD extract in it. That would be like chugging 3/4 of a bottle of sleep – LOL! I would’nt recommend this to anyone at all.
Positive side effects of CBD include: psysiological effects that include a better sense of mental well-being, anti-inflammatory effects, neuro protection effects, and antioxidant-like effects. This data is from the same study which can be seen in full below. Lets take the time to go over exactly what each of these positive side effects are, and what the study shows about the positive side effects of CBD oil.
Mental Well Being
A 4-week trial in open nature was conducted, and testing of CBD on Parkinson’s patients with symptoms that match psychosis. Doses of 150–400 mg/day (oral) CBD were administered in the last week of this trial. This led to a positive side effect in reduction of their psychotic symptoms. Even further, no serious side effects or cognitive and motor symptoms were reported.
Physiological Side Effects of CBD Oil
This next study was a double-blind, placebo-controlled crossover study. This basically means it’s a very controlled and good study. CBD was coadministered with fentanyl [via IV] to 17 subjects. Blood samples were obtained before and after 400 mg CBD or 800 mg CBD via pre-treatment. Following this CBD administration was a single 0.5 (Labeled Session 1) or 1.0μg/kg (Session 2, after 1 week of first administration to allow for sufficient drug washout) fentanyl dose via IV administration. A well-known system called The Systematic Assessment for Treatment Emergent Events (SAFTEE) was used to document both the effects and safety of the CBD administration. The SAFTEE outcomes were similar between groups. Zero depression of resperatory or complications of the cardiovascular system were recorded during any test session. According to the test result…
“The results of the evaluation of pharmacokinetics, to see if interaction between the drugs occurred, were as follows. Peak CBD plasma concentrations of the 400 and 800 mg group were measured after 4 h in the first session (CBD administration 2 h after light breakfast). Peak urinary CBD and its metabolite concentrations occurred after 6 h in the low CBD group and after 4 h in the high CBD group. No effect was evident for urinary CBD and metabolite excretion except at the higher fentanyl dose, in which CBD clearance was reduced. Importantly, fentanyl coadministration did not produce respiratory depression or cardiovascular complications during the test sessions and CBD did not potentiate fentanyl’s effects. No correlation was found between CBD dose and plasma cortisol levels.”
A study was conducted on 15 otherwise healthy male patients. This study utilized both the fMRI and questionnaires to gather data. THC (10mg d9), CBD (600mg Broad Spectrum), or a placebo was used in this double-blind, repeated measured study. The side effects of CBD was being closely monitored.
It was found that pre-treatment with CBD that had doses of Δ9-THC administration immediately following the CBD could reduce the latter’s psychotic and anxiety symptoms. This was measured using a standardized scale. Opposite signal activation of appropriate brain areas was the main effect noticed. Furthermore, no effects on peripheral cardiovascular activity such as heart rate or blood pressure were noticed.
References for studies on the side effects of CBD oil:
- Iffland, & Grotenherman. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
- Zuardi AW, Crippa JAS, Hallak JEC, et al. . Cannabidiol for the treatment of psychosis in Parkinson’s disease. J Psychopharmacol. 2009;3:979–983
- Manini AF, Yiannoulos G, Bergamaschi MM, et al. . Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans. J Addict Med. 2014;9:204–210
- Bhattacharyya S, Morrison PD, Fusar-Poli P, et al. . Opposite effects of Δ-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology. 2010;35:764–774
Have interest in purchasing any hemp-based or CBD products? Please check out our store by clicking here. If you aren’t signed up to receive updates like this and exclusive discounts on our products, please visit our homepage at www.newphaseblends.com and subscribe! It’s quick and easy.
If you find interest in reading about CBD, you should check out the eBook “CBD Essentials“, written by CBD expert and CEO of New Phase Blends, Dale Hewett.