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CBD Side Effects – What Are They?

Dale blog imageAuthor: Dale Hewett

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As CBD oil continues to gain popularity for its potential therapeutic benefits, understanding its possible side effects becomes increasingly important. At New Phase Blends, we believe in providing transparent, evidence-based information to help you make informed decisions about your wellness journey. This comprehensive guide explores the various side effects associated with CBD oil use, helping you understand what to expect and when to exercise caution

Understanding CBD Oil and Its Effects on the Body

CBD (cannabidiol) interacts with your body’s endocannabinoid system, a complex network of receptors that helps regulate various physiological processes.

While CBD oil is generally well-tolerated, its effects can vary significantly from person to person, influenced by factors such as dosage, individual body chemistry, and the quality of the product used.

How CBD Interacts with Your System

Endocannabinoid System Receptors

The endocannabinoid system plays a crucial role in maintaining bodily homeostasis, affecting everything from mood and sleep to appetite and immune response. CBD works by interacting with CB1 and CB2 receptors, as well as other molecular targets in the body. This widespread interaction explains both its therapeutic potential and the possibility of experiencing side effects.

Common Side Effects of CBD Oil

Clinical research and FDA-approved studies have identified several common side effects associated with CBD use. These effects have been documented through rigorous clinical trials. According to Current Neuropharmacology (2019), CBD side effects are studied particularly in cases related to epilepsy and psychiatric disorders, providing reliable information about what users might experience.

Fatigue and Somnolence

Research has consistently shown that somnolence and fatigue are among the most commonly reported side effects of CBD administration. These effects are notably dose-dependent, meaning they become more pronounced with higher doses. The drowsiness can be particularly intensified when CBD is taken alongside other medications, especially anti-epileptic drugs like clobazam and valproate, or when combined with other substances that cause drowsiness. If you’re using CBD, it’s important to be aware that these effects could impact your ability to drive or operate machinery safely.

Gastrointestinal Effects of CBD Use

Clinical studies have documented several digestive system effects, with diarrhea and vomiting being prominently reported side effects in human CBD trials. The severity and frequency of these effects can vary depending on factors such as dosage, the form of CBD being used, and individual sensitivity. The research suggests that these effects may be more common during the initial period of use or with higher doses of CBD.

Hepatic Impact

One of the most significant findings from clinical research is CBD’s potential effect on liver function. Studies have revealed that CBD can cause hepatic abnormalities, particularly when taken in higher doses or in combination with certain other medications. This finding emphasizes the importance of liver function monitoring for individuals using CBD regularly or in substantial doses.

More Serious Considerations and Risk Factors Associated With CBD

While CBD is generally considered safe, there are some more serious considerations that warrant attention, particularly for certain individuals or in specific circumstances.

How Does CBD Affect Your Liver Function?

Recent comprehensive research has provided clear evidence about CBD’s effects on liver function. A systematic review and meta-analysis of clinical trials published by the Journal of Internal Medicine (2023) has shown that CBD use is associated with an increased probability of liver enzyme elevation and drug-induced liver injury (DILI). The research demonstrates that approximately 7.4% of CBD users experience liver enzyme elevations, while about 3% develop DILI.

Several key risk factors have been identified through this research. High-dose CBD consumption, defined as 1000 mg per day or more (or 20 mg/kg/day), carries a significantly higher risk. Additionally, people taking antiepileptic medications alongside CBD face an increased risk of liver-related side effects. However, it’s important to note that no cases of liver enzyme elevation were reported in adults using CBD doses below 300 mg per day, and no severe cases of drug-induced liver injury were documented in any of the studies (Livertox 2023).

Given these findings, medical professionals now recommend liver function monitoring for CBD users, particularly those taking higher doses or using other medications. This is especially crucial for individuals with pre-existing liver conditions or those using CBD in combination with other medications that affect liver function.

Drug Interactions

CBD can interact with various medications by affecting the cytochrome P450 enzyme system, which is responsible for metabolizing many pharmaceutical drugs. This interaction can potentially alter the effectiveness of medications or increase the risk of side effects. Read our article on CBD interactions with medications for more information.

CBD Safety For Sensitive Groups

Currently, there is limited research on the safety of CBD use during pregnancy or while breastfeeding. Given this uncertainty, it’s generally recommended to avoid CBD use during these periods unless specifically advised by a healthcare provider.

Older adults may be more sensitive to CBD’s effects and are more likely to be taking multiple medications that could interact with CBD. Starting with lower doses and careful monitoring is particularly important for this population.

Minimize Side Effects Through Product Quality

The quality of CBD oil can significantly influence the likelihood and severity of side effects. At New Phase Blends, we emphasize the importance of choosing high-quality, third-party tested products. Poor quality CBD products may contain various concerning elements such as contaminants, incorrect CBD concentrations, unexpected THC levels, or heavy metals and pesticides. These impurities can lead to additional unwanted side effects or health concerns.

Quality assurance in CBD products involves several key components that consumers should look for. Reputable products should come with comprehensive Certificates of Analysis (COA), detailed third-party laboratory test results, clear ingredient listings, and transparent manufacturing processes. These elements help ensure you’re getting a safe, reliable product that meets claimed specifications.

Minimizing Negative Effects and Optimizing Benefits

To minimize the risk of side effects while maximizing potential benefits, several key practices should be followed. Beginning with a low dose and gradually increasing as needed allows your body to adjust and helps identify your optimal dosage. Taking CBD with food can improve absorption and reduce gastrointestinal effects.

Keeping a journal to track effects helps identify optimal dosing patterns, while choosing high-quality products from reputable manufacturers ensures consistency and safety. Maintaining consistent timing of doses can also help optimize results.

When to Consult a Healthcare Provider

Medical consultation is particularly important for certain individuals before starting CBD use. This includes people taking prescription medications, those with pre-existing health conditions, pregnant or breastfeeding individuals, anyone experiencing unexpected or severe side effects, and those planning long-term CBD use. Healthcare providers can offer personalized guidance based on your specific situation and medical history.

Monitoring and Adjust Your CBD Usage To Minimize Side Effects

Careful monitoring of your body’s response to CBD is essential for optimal results. Pay attention to any changes in sleep patterns, mood alterations, digestive changes, energy levels, and any unexpected symptoms. These observations can help guide adjustments to your CBD usage for better outcomes.

Making Dosage Adjustments

When side effects occur, several adjustment strategies may help improve your experience. Consider reducing your dosage, altering the timing of your doses, trying a different product formulation, or incorporating short breaks between usage periods. These modifications can help you find the right balance for your body.

Conclusion: Making Informed Decisions About CBD Use

Understanding the potential side effects of CBD oil is crucial for safe and effective use. While CBD offers promising benefits for many users, being aware of possible side effects and knowing how to minimize risks can help you make informed decisions about your wellness journey. Remember that individual responses to CBD can vary significantly, and what works for one person may not work for another.

Learn More About Pure CBD Oil

At New Phase Blends, we’re committed to providing high-quality CBD products and educational resources to support your wellness goals. Before starting CBD oil, consider consulting with a healthcare provider, particularly if you have underlying health conditions or take medications. By staying informed and mindful of your body’s response, you can work toward finding the right CBD solution for your needs while minimizing potential side effects.

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About the Author - Supplement Expert Dale Hewett

Dale Hewett Author
Dale Hewett

Dale Hewett is the owner and founder of New Phase Blends. He discovered his passion for CBD use after suffering from injuries sustained while on Active Duty in the US Army. His number one priority is introducing the same CBD products that he himself uses for relief to others who can benefit from them. This led to the discovery of other useful, natural supplements that most people aren’t familiar with, but can make a great difference for our bodies.

Dale holds a Master Degree of Science, and is the inventor of the popular, CBD-based sleep aid known as ‘Sleep.’ He’s given multiple lectures on CBD to institutions such as Cornell’s MBA student program, and Wharton’s School of Business.

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