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A Patient’s Guide to CBD and Medication Interactions

Dale blog imageAuthor: Dale Hewett

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If you’re considering adding CBD to your wellness routine while taking other medications, you need to understand the potential interactions between them. This comprehensive guide will help you make an informed decision about CBD use alongside your current medications.

Understanding How CBD Affects Your Medications

When you take CBD, it interacts with a family of enzymes called CYP450, which are responsible for processing many medications in your body. Your liver uses these enzymes to break down both CBD and many prescription drugs. When CBD is present, it can either slow down or speed up how your body processes certain medications.

This interaction might increase the medication’s effects, potentially leading to stronger side effects. Alternatively, it could decrease the medication’s effectiveness or change how long the medication stays in your system. Understanding these interactions is crucial for your safety and the effectiveness of your medications.

Medications That Require Special Attention

Several categories of medications require particular caution when combined with CBD. Blood thinners and blood pressure medications need precise dosing, and CBD may affect their concentration in your bloodstream. Anti-seizure medications and heart rhythm medications could have their effectiveness impacted by CBD use. Mental health medications, including antidepressants, anti-anxiety medications, and mood stabilizers, may also be affected by CBD’s presence in your system.

The Importance of Medical Guidance

Before combining CBD with any prescription medications, consulting your healthcare provider is essential. This is particularly important if you notice a “grapefruit warning” on your prescription bottles, as these medications typically interact with CBD. The way CBD affects your body’s processing of medications means you should never stop or adjust your prescribed medications without medical supervision.

Over-the-Counter Medication Interactions With CBD

Many people want to know about combining CBD with common over-the-counter medications, particularly acetaminophen (Tylenol). While many people take both substances without issues, it’s important to understand that both are processed by your liver. Taking them together increases the workload on your liver, which is why healthcare providers often recommend using lower doses of both substances when combined. Your healthcare provider can give you specific guidance about dosing in your situation.

Understanding the “Grapefruit Warning”

grapefruit warning chart

A practical way to identify potential CBD interactions is to look for grapefruit warnings on your medications. This connection exists because both CBD and grapefruit affect similar enzyme systems in your body. When you see this warning, it signals the need for a detailed discussion with your healthcare provider about CBD use.

Creating a Safe Plan For Mixing CBD With Other Medications

Creating a safe plan for CBD use requires careful preparation and ongoing monitoring. Start by creating a comprehensive medication review document that includes every substance you take. Note the name, dosage, and timing of each prescription medication, as well as any over-the-counter medicines, vitamins, minerals, and herbal supplements. Even seemingly minor supplements can interact with CBD, so include everything you take regularly or occasionally.

When preparing for your healthcare consultation, gather information about why you’re interested in CBD and what specific benefits you hope to achieve. Your provider will need this context to evaluate whether CBD might help your situation and how it could affect your current medications. During the appointment, be prepared to discuss your complete medical history, including any past reactions to medications or supplements.

Involve Your Healthcare Provider

Your healthcare provider might need to conduct baseline blood tests or other assessments before approving CBD use. These tests can provide important reference points for monitoring how CBD affects your medication levels. Your provider may also want to check your liver function, as both CBD and many medications are processed by the liver.

If your provider determines CBD is safe to try, they’ll help you develop a careful introduction plan. This typically begins with selecting an appropriate CBD product and starting dose. Your provider might recommend specific types of CBD products (such as oils, capsules, or topicals) based on your medical needs and current medications. They may also suggest certain times of day to take CBD to minimize potential interactions with your other medications.

Schedule regular check-ins with your healthcare provider during the first few months of CBD use. These appointments allow your provider to monitor your progress and assess any changes in your medication levels or overall health. They might recommend blood tests to check medication levels or adjust dosages of either CBD or your prescribed medications based on your response.

Start With the Lowest Possible Dose

When you begin taking CBD, start with the lowest possible effective dose and maintain detailed records of your experience. Note the exact amount you take, the time of day, and any effects you notice – both positive and negative. Pay particular attention to changes in how you feel, your sleep patterns, and any side effects from your regular medications, as these might indicate an interaction.

Keep a symptom diary during this time, recording any changes in your condition, side effects, or concerns. This information helps your healthcare provider make informed decisions about continuing or adjusting your treatment plan. Remember that finding the right balance may take time and require several adjustments to achieve optimal results while maintaining your safety.

Special Considerations for Chronic Conditions

Managing chronic pain or mental health conditions requires extra care when incorporating CBD. If you’re taking prescription medications for chronic pain, maintaining your current treatment while working with your doctor to safely incorporate CBD is important. Mental health medication levels need particularly careful monitoring, as changes can significantly impact your well-being. Your mental health provider can help you develop a plan that safely includes CBD if appropriate.

Summary

Maintaining open communication with your healthcare team is crucial for safe CBD use. Regular discussions with your pharmacist, attention to FDA updates on CBD safety, and participation in condition-specific support groups can help you stay informed. The key to safely using CBD alongside other medications lies in this ongoing dialogue with your healthcare providers and complete honesty about all substances you’re using or considering.

Remember that your safety comes first. Working closely with your healthcare team and being patient with the process of incorporating CBD into your treatment plan will help ensure the best possible outcomes for your health and well-being.

Balachandran P, Elsohly M, Hill KP. Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review. J Gen Intern Med. 2021 Jul;36(7):2074-2084. doi: 10.1007/s11606-020-06504-8. Epub 2021 Jan 29. PMID: 33515191; PMCID: PMC8298645.

Gaston TE, Bebin EM, Cutter GR, Grayson L, Szaflarski JP. Final analysis of potential drug-drug interactions between highly purified cannabidiol and anti-seizure medications in an open-label expanded access program. Epilepsia Open. 2023 Dec;8(4):1405-1412. doi: 10.1002/epi4.12815. Epub 2023 Aug 26. PMID: 37593907; PMCID: PMC10690661.

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When it comes to understanding both the science and benefits of cannabidiol (CBD), it is extremely important that you can trust the source of your information. This is exactly why our team at New Phase Blends includes experts in the field of cannabinoid research and development, including frequent correspondence with certified medical professionals and PhDs in relevant fields via studies, research, and additional peer reviewed pieces of information. All information published is reviewed and checked for accuracy. We pride ourselves on staying up-to-date with the latest scientific research and clinical studies related to not only CBD, but also its effects on the human body.

About the Author - CBD Expert Dale Hewett

Dale Hewett Author
Dale Hewett

Dale Hewett is the owner and founder of New Phase Blends. He discovered his passion for CBD use after suffering from injuries sustained while on Active Duty in the US Army. His number one priority is introducing the same CBD products that he himself uses for relief to others who can benefit from them.

Dale holds a Master Degree of Science, and is the inventor of the popular, CBD-based sleep aid known as ‘Sleep.’ He’s given multiple lectures on CBD to institutions such as Cornell’s MBA student program, and Wharton’s School of Business.

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