WHAT IS CANNABIDIVARIC ACID (CBDVA)?

Like other cannibinoids, Cannabidivarinic Acid (CBDVA) is  found in Cannabis sativa and is the precursor of Cannabidivarin (CBDV) and has anti-inflammatory properties.

Having anti-inflammatory properties means it is capable of remedying pain by reducing inflammation. This is opposed to opioids, which affect the central nervous system by blocking pain signs to the brain. This implies cannabidivarinic acid (CBDVA) can work as a an analgesic to reduce pain and inflammation.

Little is known of when and how cannabidivarinic acid (CBDVA) was identified but insights can be drawn from when its precursor was first identified. The A indicates that this compound is an acid, and thus written out as cannabidivarinic acid (CBDVA).

Research unfortunately, has been hamstrung by the DEA Controlled Substances Act, and certified reference material is lacking. What is needed to circumvent this is a DEA exempt solution format.

Although first isolated in 1969 by Vollner, et al., CBDV was probably first reported in a benzene extract from a Thai Cannabis variety referred to as “Meao”.

It’s important to state that cannabinoids are derived from plants in the Cannabis genus, mostly hemp and marijuana. Cannabinoids interact with the available cannabinoid receptors in the human body which are part of the human endocannabinoid system. This system helps regulate ones homeostasis.

The prefix “Endo” at the beginning of the word indicates that it is produced in the body. Thus, endocannabinoids are the cannabinoids produced by the human body to help regulate the systems that control pain, appetite and neurological functions. These include things such as cognitive function, cranial nerves, motor strength, sensation, reflexes, coordination, and gait. 

Additionally, it enhances functions including self-monitoring, organization, motor planning and initiation (expression language), attention and concentration, mental inflexibility, behavioral inhibition, personality and awareness of abilities and limitations to mention but a few.

Very little is known of CBDVA. Just like the CBDV, it has received little attention and is short of certified reference material. That said, it is expected to become a more interesting area of research in the near future. Despite this, it is evident that cannabidivarinic acid (CDBVA) possesses properties and potential benefits.

HOW IT WORKS

CBDVA testing methods must be precise, and in house standards preparation of these compounds should reflect this. Lets review some findings.

Anderson, et al in their study on the effect of cannabidiolic acids in a Mouse Model of Dravet Syndrome, recorded that rapid absorption of CBDVA was observed following intraperitoneal (i.p.) administration with a plasma tmax of 15 min and a t1/2 of 49 min. Absorption into the brain was slightly delayed, as the tmax was 30 min; however, the Cmax was quite low and elimination was rapid (t1/2 19 min).

At 60 min, CBDVA was detected in brain tissue but was below the limit of quantification (LOQ), so a value of 1/2 LOQ (0.25 ng/mg brain) was used. Elimination was complete by 90 min. The brain−plasma ratio (0.02) suggests CBDVA exhibits poor brain penetration.

The neutral form of CBDVA, CBDV, was not detected in the brain or plasma following injection of CBDVA, suggesting there is no significant decarboxylation of CBDVA to CBDV in vivo following i.p. injection. These tests were all done with isolate forms of these compounds; prepared stock product eliminates variables which could contaminate testing samples.

This certified reference material suggests that cannabidivarinic acid, being a cannabidiolic acid (CBDA), can serve as a anticonvulsant against Hyperthermia induced Seizures.

THERAPEUTIC BENEFITS

Although little is known of CBDVA, this is not an indication that it is without therapeutic benefits. It is a cannabinoid and cannabinoids are known for easing anxiety, slow tumor growth, eradication of cancer cells, reducing symptoms of nausea and vomiting, stimulating appetites, muscle relaxation, and reducing seizure activity. 

Specifically, CBDVA has a capacity for anti-inflammatory benefits that can ease arthritis pain, swelling from an injury, and constant pain from chronic conditions. These effects are demonstrated via certified reference material.

INTERESTING FACTS

CBDVA has no capacity to induce a “high” when used. Only quality products can be used this way. High quality, prepared stock product guarantees this.

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Rerences

Lyndsey L. Anderson, Ivan K. Low, Samuel D. Banister, and Jonathon C. Arnold, “Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome” Journal of Natural Products.

Shoyama, Y., Hirano, H., Makino, H., Umekita, N., Nishioka, I., 1977. Cannabis. X. The isolation and structures of four new propyl cannabinoid acids, tetrahydrocannabivarinic acid, cannabidivarinic acid, cannabichromevarinic acid and cannabigerovarinic acid, from Thai cannabis, FMeao variant_. Chemical and Pharmaceutical Bulletin 25 (9), 2306–2311.

Vollner L, Bieniek D, Korte F. 1969. Hashish. XX. Cannabidivarin, a new hashish constituent. Tetrahedron Letters 3:145–147 DOI 10.1016/S0040-4039(01)87494-3. Amada et al. (2013), PeerJ, DOI 10.7717/peerj.2141

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