Can I Mix CBD Oil with Melatonin?

So you’re laying in bed again having trouble sleeping, again. I hate that feeling. The feeling you get when it becomes harder and harder to fall asleep because you know you are losing sleep every minute that goes by when you aren’t asleep. You know about both CBD and melatonin, but can you take CBD oil with melatonin? Can you mix CBD oil with melatonin? Will it help me fall asleep? The short answer is yes, but it’s not that simple.

What is melatonin?

Let’s take a minute to familiarize ourselves with melatonin, and EXACTLY what it is – and how it works…

Man’s existence has always relied on natural remedies like the use of plants and plant-based extracts as a remedy for disease conditions, including those relating to sleep disorders. These plants have been discovered to possess a vast concentration of phytochemicals (plant-based chemicals) capable of interacting with the body cells in order to proffer solutions to health challenges.

Phytochemicals are secondary metabolites synthesized by the plant to protect itself from the harsh nature of the environment. Most of these items were produced to shield the plant from the activities of pests and diseases. Phytochemicals can act singly or in synergism to elicit a therapeutic role in diseases and the health of the body.

melatonin molecule

How does melatonin help me sleep?

According to the Journal of Psychiatry and Neuroscience, “Melatonin is a hormone responsible for controlling your natural sleep-wake cycle.” The natural levels of these hormones are highest in the blood at night, thus the reason why some researchers believe supplements containing this hormone can serve important roles in sleep-related disorders like providing relief from insomnia, jet lag, and delayed sleep phase. As effective as it may sound, melatonin is safer for short-term use, and unlike other sleep medications, it produces little to no side effects like addiction or experiencing a diminished response after continuous use. Melatonin supplements are commonly available in pill form and can be administered by simply swallowing the pill. Regardless of the method of administration, the aim is to allow a direct absorption of the hormone into the bloodstream, just like CBD.

cbd mixed with melatonin
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Melatonin plays a significant role in regulating our night and day cycles or sleep-wake cycles. The production of melatonin is triggered by darkness, which signals the body to get ready for sleep. The presence of blue light tends to reduce the concentration of melatonin in circulation, thus allowing us to be awake throughout the day. Low levels of melatonin are often linked to sleep disorders, hence the need to add utilize these supplements to strike a balance. It is pertinent to note that while melatonin plays a vital role in the sleep-wake cycle, it does not put you to sleep; rather, it alerts the brain of the need to fall asleep. Have you tried experimenting with melatonin before, and it didn’t work for you? Or, perhaps it made you feel a little sleepy, but didn’t put you to sleep? That’s where CBD comes in handy…

How can I mix CBD oil and melatonin?

You’ve heard CBD can help relax people, and for some even help them sleep. You know melatonin is a proven substance that helps you sleep. Then you ask yourself, “Can I take my CBD oil with melatonin?”

The short answer is YES, but you can only mix CBD and melatonin in a certain manner for maximum results. Generally, people take CBD gummies for sleep 30 minutes before going to bed for better results. The quantity of CBD and melatonin varies in different situations. Both CBD-rich hemp extract and melatonin are natural supplements, and together they do a fantastic job in the fight against Insomnia. To get the best benefits from both of these supplements, the extract, melatonin, and a range of cannabinoids must be precisely measured and dosed. This is something that, unfortunately, can’t be done in our homes. New Phase Blends has a patent-pending product called ‘sleep‘ that revolves around the mixture of melatonin and phytocannabinoids, like CBD. The issue is not whether or not you can mix it, it’s more like: what is the most effective way to mix the two?

We already know that the bio-availability of a substance broken down by your stomach is minimal, at best. So while you could technically eat your CBD, then eat some melatonin, the effects will most likely be very low. This can only deliver about 20% of the overall consumed substances to your bloodstream. Oral consumption of CBD depends on enzymatic activation and may lead to waste. If you’re interested, read more about the most effective methods for CBD consumption.

What are good products that mix CBD oil and melatonin?

Enter “Sleep” by New Phase Blends. We took the time to develop the most effective way (other than directly injecting into the bloodstream which is HIGHLY dangerous and NOT RECOMMENDED AT ALL!) to mix your melatonin and CBD. While our provisional patent covers this in depth, we essentially take the time to mix the highest grade, premium melatonin with a very potent and high grade broad spectrum CBD while making the extract in our labs. This results in a very, very effective sleep aid that is rapidly growing in popularity on the market today. It’s even been featured in magazines like Vogue, and expert CBD websites such as CBD School. “Sleep” (click here for more information) is our flagship product, and helps thousands of people around the world achieve a deep, real sleep. This product is all based on the science that we’ve talked about so far.

The interaction between CBD and the endocannabinoid system is integral to maintaining both internal and hormonal balance. The Journal of Psychopharmacology shows us that “A study conducted in 2013 discovered that small doses of CBD in rats could increase the total sleeping time even though this activity was more pronounced during the dark portion of the day.” The activity of CBD and sleep is determined by the time of administration and the dosage. In the experiment, the researchers administered intraperitoneal injections containing 2.5 mg/kg, 10 mg/kg, and 40 mg/kg of CBD on Adult male Wistar rats. The researchers went ahead to observe the sleep recordings during the light and dark periods for four days. At the end of the experiment, it was discovered that the sleep percentage increased in groups treated with 10 and 40mg/kg of CBD compared to placebo thus leading them to conclude that the acute systemic administration of CBD appears to increase total sleep time in addition to increasing sleep latency in the light period of the day. The findings of the study point to the ability of CBD to interact with serotonin and GABA receptors in the brain.

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According to an article titled The Expanded Biology of Serotonin, “Serotonin is a neurotransmitter that is required for the proper regulation of anxiety and mood.” GABA is a primary inhibitory neurotransmitter required for the reduction of excess activity in the nervous system. These two natural chemicals in our bodies can be influenced by CBD use. There is also an increased level of research indicating how CBD could act to promote anti-anxiety effects while sleeping. While small doses of CBD could stimulate alertness during the day, heavy CBD doses could trigger sleep at night.

The activity of CBD and melatonin seems to be complementary even though they are regulated by different portions of the brain. Melatonin tells your body its time to fall asleep while CBD alerts your brain to recruit the right neurotransmitters to allow you to fall asleep. CBD can also take care of the underlying conditions leading to reduced sleep, thus producing a much longer effect.

Be careful who you purchase your CBD-based sleep aids from!

For those of you that are familiar with the cannabidiol, or CBD, marketplace, you know that it’s still an unregulated item by the FDA. This means that it cannot be referred to as a dietary supplement. Just because hemp was decriminalized and made legal in 2018 doesn’t mean that the FDA has developed a way to regulate the product. That means that while there are some very good companies out there that sell a good product, there are also companies out there trying to take advantage of people.

These “bad CBD companies” are selling either under dosed, mislabeled, or just plain fake CBD. For instance, did you know that hemp-seed oil has no CBD in it? CBD products aren’t cheap. I would hate to see you spend your hard earned money on purposefully mislabeled CBD oil, only to find out it’s just hemp seed oil. Hemp seed oil really offers little to no beneficial cannabinoids at all. It’s commonly used as a cooking oil. You can read more about the scams associated with CBD by clicking here.

My intent isn’t to scare you into buying New Phase Blends products, it’s to make you more aware. Do your research on who you are buying from before clicking that buy button. Get your CBD sleep aid from a trusted buyer. Taking a little extra time to vet companies is worth it in the long run!

I hope you got some value from this blog post, as it’s a very popular question. Mixing CBD oil with melatonin, if done properly, can result in an excellent sleep aid. Just remember, New Phase Blends holds a patent-pending product called CBD oil for sleep that can aid your sleepless nights – it’s also shipped for FREE!

The Expanded Biology of Serotonin:
Journal of Psychiatry and Neuroscience:
National Library of Medicine:
Journal of Psychopharmacology:
National Institute of Health:
Ministry of Hemp:

Have interest in purchasing any hemp-based or CBD products? Please check out our store by clicking here. If you aren’t signed up to receive updates like this and exclusive discounts on our products, please visit our homepage at and subscribe! It’s quick and easy.

If you find interest in reading about CBD, you should check out the eBook “CBD Essentials“, written by CBD expert and CEO of New Phase Blends, Dale Hewett.

cbd ebook

8 thoughts on “Can I Mix CBD Oil with Melatonin?”

    1. Thanks so much for your feedback! Our flagship product, SLEEP, works wonders and its all because of the science-backed evidence we kept in mind while doing product development for this sleep aid.

  1. Samantha Talbot

    I had no idea what melatonin was until after reading this. Seems like a great product you have. Thanks for providing this information without shoving advertisements down my throat as I read it.

  2. First of all, outstanding article. You are a great writer. Secondly, I ended up buying a bottle of the sleep tincture and I feel obligated to let you know that this is the best sleep aid I’ve ever tried in my life. The ONLY thing that may work better at putting you to sleep that I’ve tried is Ambien, but that is an insanely dangerous drug that makes me do things I don’t remember. I will be purchasing this sleep aid from you for the rest of my life, or as long as you are around as a company. I’m truly THAT IMPRESSED!

  3. I bought sleep after reading the article. I was taking melatonin pills with cbd pills and it doesn’t work anywhere near as good. I’m impressed.

  4. I have been using your sleep products for almost a year. Thanks for making products like this – nothing else has worked for me.

  5. Christopher McNielsons

    I came here trying to figure out if I can take my melatonin powder with my cbd oil. It hasn’t been working that great when I do it, so I bought a soothe from you so I could get the free sleep cbd product sample like the promo on this page says. It came in the mail last week and I am sleeping like a rock now.

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