WHAT IS DELTA-9-TETRAHYDROCANNABIVARINIC ACID (THCVA)?

Delta-9-tetrahydrocannabivarinic acid (THCVA) is an acidic compound found in the cannabis plant. It is the acidic form of THCV. It shares the same parents with THCV and carboxylic acid. THCVA, like THCA, is one of the very few cannabinoids currently being sold by manufacturers and companies alike. The sales of cannabis compounds and the use of marijuana are illegal in some countries, but this hasn’t dissuaded the increase of these compounds on the market.

CBD was discovered some 80 years ago by researchers. Today, there are about 130 cannabinoid compounds that have been discovered. THCVA, discovered not so long ago, is gotten from the oxidation of the THCV compound. There is currently no record to tell when, how, or who discovered the THCVA compound.

THCVA is formed from the CGBVA compound. The CGBVA compound is known as the mother compound. THC, CBN, CBT, THCV, and other constituents of the cannabis plant are said to stem from the continuous oxidation of CGBVA. THCVA undergoes the chemical reaction known as decarbonation, just like other cannabinoids.

The isolation of the THCVA compound from others has proven easy for chemists. The compound itself is available to be bought on the market in some countries. The future of this compound is a little better than bright. Researchers and the medical field are interested in the compound. Its features and functionalities, like the THCV compound, give it a high level of interest compared to the other cannabidiols that exist.

HOW DOES THCVA WORK?

There are few to zero published articles or findings on the mechanisms by which this compound performs its actions. We currently know little about how THCVA combines with receptors and acts. Its mixture with other CBD compounds and reactions at receptors CB1 and CB2 are unknown.

We know that THCV is a receptor antagonist at CB1 and a partial receptor agonist at CB2. If the acidic form of this compound will react the same way or in a different manner is a question yet to be answered in the field of study. More research will identify the functions of THCVA, and we can only hope that researchers start to look into it earnestly

POSSIBLE THERAPEUTIC BENEFITS

The possible therapeutic benefits of THCVA are still unknown. We don’t know its effects and functions in the body. In a bid to assume, here is what we know about the compounds similar to THCVA. We know that the THCV compound can treat neurological ailments, help bone growth, and is a stimulant euphoriant. We also know that THC is a psychoactive drug and has the same therapeutic abilities as well. We are aware that a variety of compounds stemming from CGBVA all have therapeutic benefits. Yet, we still don’t know enough about THCVA except that it is one of the most promising CBD compounds.

INTERESTING FACTS

  1. Its formula is C19H24O4.
  2. Its molar mass is 330.4 g/mol.
  3. THCVA has a hydrogen bond donor count of 2, hydrogen bond acceptor count of 4, and a rotatable bond count of 3.
  4. By annotation, the THCVA compound is similar to altenuene, atranorin, quinquanguline & delta (9)-Tetrahydrocannabinolic acid.

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References

National Center for Biotechnology Information. PubChem Compound Summary for CID 59444416, delta9-Tetrahydrocannabivarinic acid

Husni, Afeef, “Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2” (2012). Electronic Theses and Dissertations. 1459.

Karniol IG, Shirakawa I, Takahashi RN, Knobel E, Musty RE (1975). “Effects of delta9-tetrahydrocannabinol and cannabinol in man”. Pharmacology. 13 (6): 502–12. doi:10.1159/000136944.

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