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What is Cannabichromevarinic Acid (CBCVA)?

Cannabichromevarinic acid (CBCVA) is a unique compound produced exclusively by the Cannabis plant. Marijuana, a type of Cannabis, contains numerous chemical compounds that contribute to its distinct characteristics. It is derived from the leaves, dried flowers, stems, and seeds of Cannabis plants.

Cannabinoids, which include cannabichromevarinic acid, are some of the most influential chemicals in marijuana. Endocannabinoids from the human body interact with phytocannabinoids from the Cannabis plant, causing various physiological effects.

More than 110 cannabinoids exist, with CBCVA being a potent member of the cannabinoid family alongside CBD, THC, CBC, and CBG. CBD and related compounds, such as Cannabichromevarinic Acid, are non-intoxicating. In fact, it has been suggested that CBD and its associated compounds in the cannabis plant may counteract some of the potentially undesirable side effects of THC.

CBCV was initially discovered at the University of Nagasaki in 1975 from marijuana sourced from Thailand, and subsequently reported in scientific literature in 1980. CBCV is not considered psychoactive or impairing, and is believed to be safe for both children and adults. It is a compound found in medical marijuana.

Natural CBC-C5 is believed to be racemic, and the CBC acids, cannabichromenic acid and cannabichromevarinic acid, have been reported to exhibit optical activities of +4.8 and 4.8- in chloroform, respectively. Both acids have been confirmed as A acids through IR data and comparison with synthetic samples.

Cannabinoids typically exhibit poor solubility in water but dissolve well in alcohol, lipids, and various non-polar organic solvents.

Therapeutic Benefits of CBCVA

Cannabichromevarinic Acid, as a significant compound in cannabinoids, interacts with the human body’s nervous system, enhancing hormonal functionality and promoting balanced appetite, sleep patterns, mood, and movement.

Additionally, it serves various purposes:

  1. It functions as a pharmacological agent in treating epileptic seizures, bipolar disorder, and borderline personality disorder.

  2. Cannabichromevarinic Acid alleviates pain by decreasing inflammation and swelling.

  3. As an antioxidant, it protects body cells against free radicals, which may contribute to heart disease, cancer, and other illnesses.

  4. It can be utilized to manage psychosis, functioning as either an antipsychotic or neuroleptic.

  5. Cannabichromevarinic Acid can act as an immunomodulator, helping to regulate or normalize the immune system.

  6. As a cannabinoid, it serves as a neuroprotective agent, reducing signs of oxidative stress.

CBCVA: Interesting Facts

Cannabichromevarinic acid (CBCVA) is a relatively lesser-known cannabinoid found in the Cannabis plant. Here are some interesting facts about CBCVA:

  1. Unique origin: CBCVA is produced exclusively by the Cannabis plant, making it a unique compound with a specific origin.

  2. Non-intoxicating: Unlike THC, which is responsible for the psychoactive effects associated with marijuana, CBCVA is non-intoxicating and doesn’t cause impairment.

  3. Wide-ranging potential benefits: CBCVA has been researched for its potential therapeutic benefits, including anti-inflammatory, antioxidant, neuroprotective, antipsychotic, and immunomodulatory properties.

  4. Rare compound: CBCVA is a relatively rare cannabinoid, found in smaller concentrations compared to more well-known cannabinoids like THC and CBD.

  5. Precursor to other cannabinoids: CBCVA serves as a precursor to CBC (Cannabichromene), another non-intoxicating cannabinoid with potential therapeutic benefits.

  6. Discovery: CBCVA was first identified in 1975 at the University of Nagasaki, Japan, from marijuana sourced from Thailand.

  7. Solubility: Like other cannabinoids, CBCVA is almost insoluble in water but soluble in alcohol, lipids, and various non-polar organic solvents.

Please note that research on CBCVA is still limited, and more studies are required to fully understand its potential benefits, side effects, and interactions with other compounds.


Steve, K., CBCVA – Cannabichromevarinic acid – Uniquely Produced by Cannabis Plant,

Gaoni, Y., Mechoulam, R., 1971. Isolation and structure of D1-tetrahydrocannabinol and other neutral cannabinoids from hashish. Journal of the American Chemical Society 93 (1), 217–224.

Shoyama, Y., Hirano, H., Makino, H., Umekita, N., Nishioka, I., 1977. Cannabis. X. The isolation and structures of four new propyl cannabinoid acids, tetrahydrocannabivarinic acid, cannabidivarinic acid, cannabichromevarinic acid and cannabigerovarinic acid, from Thai cannabis, FMeao variant_. Chemical and Pharmaceutical Bulletin 25 (9), 2306–2311.

Shoyama, Y., Fujita, T., Yamauchi, T., Nishioka, I., 1968. Cannabis. II. Cannabichromenic acid, a genuine substance of cannabichromene. Chemical and Pharmaceutical Bulletin 16 (6), 1157–1158.

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