This article will address the differences of CBC vs CBD, and help you leave with a better understanding of the CBC cannabinoid. Most of us are already familiar with two the two more-famous cannabinoids within cannabis: CBD and THC. While these two cannabinoids are useful, other cannabinoids have much to offer.
CBC, or cannabichromene, is one of many cannabinoids that still hasn’t hit the limelight. Let’s compare these two cannabis compounds, the similarities they share, and the differences they have. While cannabinoids may look similar from the outside looking in, there are, in fact, a lot of differences.
Since the Farm Bill of 2018 passed, CBD has received a vast majority of the media attention. CBN and CBG, with their non-psychoactive properties, quickly followed CBD and are also available in the marketplace now. If interested, check out this article on comparing the differences between CBN vs CBD. This goes to show the speed at which research has been conducted since industrial hemp was decriminalized. CBC will follow in these footsteps.
A Short History of CBC
It’s completely understandable if you haven’t heard about cannabichromene, or more commonly known as CBC. It was discovered in 1966 by Dr. Raphael Mechoulam and Y. Gaoni. CBC hasn’t received too much attention to date. However, CBC is a prominent cannabinoid that has been considered for use because of its potential therapeutic benefits.
When discussing CBC vs CBD, keep in mind that cannabichromene (CBC) is quickly emerging as one of the popular cannabinoids of recent times. CBD, on the other hand, remains just as prevalent – if not more so than THC. A study in 1981 assumed that CBC was the second-most abundant compound in the plant, even exceeding the quantities of CBD.
If this is true, then we desperately need to understand how to develop a CBC rich strain and determine the medicinal properties, if they exist.
CBC gained traction right after the distinction was made between CBD and CBG. That being said, there still aren’t any cannabis Sativa strains that highlight high concentrations of CBC. As we’ve seen with CBD, though, that could very well change – and change fast. High CBD strains are now famous, and twenty years ago, they weren’t.
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Like many other cannabinoids, CBC is commonly mistaken with CBD. CBC is a different compound and has a unique chemical structure (C21H30O2), as you can see in the info graphic above. Also, CBC exerts other effects when compared to CBD. We’ll get into these later on.
The primary source of extracting CBC is via CBGa (cannabigerolic acid) instead of processing hemp flower or other portions of the hemp plant. Cultivators need to do this since they cannot count on harvesting high-CBC yield strains. CBGa is a “stem cell” compound that is a precursor to many different cannabinoids. THC, CBD, and CBC all share the same origin of formation: cannabigerol acid (CBGA).
CBG converts and produces CBC in two different forms by means of an activated enzyme process. According to Pharmacology in Drug Discovery (2012), “Enzyme activation can be accelerated through biochemical modification of the enzyme (i.e., phosphorylation) or through low molecular weight positive modulators.”
Image credit: Pharmacology in Drug Discovery, 2012
Potential Benefits Of CBC | CBC vs CBD
CBC has become a source of attraction in the medical field because of its’ potential therapeutic effects, just like CBD, CBN, and CBG. As a bonus, CBC is non-psychoactive. Non-psychoactive compounds are always better in the medical community, because it eliminates the potential of physical addiction.
The medical benefits of CBC are quite promising, but they need a bit more research. The cannabis plant generates CBGA, which then turns into three significant cannabinoids: CBD, CBC, and THC. There is a little more to it, but that’s all we’ll cover for now regarding CBGA.
The cannabis Sativa plant is full of useful cannabinoids, and existing chemical research proves this claim. When talking about CBC vs CBD, scientists have discovered CBC’s potential value and have identified a few potential benefits of this cannabinoid.
A Study on CBC in the Treatment of Cancers
In 2006, CBC was first researched to proclaim its potential benefits for cancer during a study to understand the effects of cannabinoids on tumor size and cancer progression. In 2012, a breast cancer study, again, included anandamide and CBC in it’s trials. CBC has convinced scientists that it is worth-investigating because of its potential cancer-fighting and pain-relieving qualities.
There is no further research present in this regard to understanding the relation between CBC and cancer. That is what makes it challenging to evaluate this cannabinoid’s potential effect on cancerous cells.
Studies on CBC For Neurological Health
A study made on CBC in 2013 showed CBC’s potential effects for promoting adult neural stem progenitor cells (NSPCs). These cells are an essential part of the brain. They convert into astroglial cells. Astroglial cells handle the passage of neurotransmitters everywhere in your brain and nervous system.
The strength of these cells prevents the risks of Alzheimer’s disease and other neurodegenerative conditions. In this area, CBC has given the green light for further research in improving neurological health.
CBC May Possess Analgesic Benefits
As cannabinoids interact with different receptors located in our bodies. For example, the TRPV1 receptor is responsible for controlling the feeling of inflammatory pain in the human body.
Example of an andrenergic receptor
CBC, in initial research, has shown that it has a higher chance of interacting with the nervous system’s TRPV1 receptors than CBD. It also interacts with the CB2 receptor. Based on this research, CBC came about as an effective analgesic.
In another study, Turner and Elsohly concluded, “Anti-inflammatory activity was evaluated by the carrageenan-induced rat paw edema and the erythrocyte membrane stabilization method. In both tests, CBC was superior to phenylbutazone.”
It appears that CBC may help in relieving the pain related to arthritis and many other conditions. Again, we need more research.
CBC Vs CBD | What is the Difference?
CBC, along with THC and CBD, is one of the most prevalent compounds in cannabis. All of the potential benefits mentioned above about CBC are based on limited research, which is still not enough to make any medical claims. It is still too early to stamp out CBD’s effectiveness for use as a cancer treatment or any other ailment.
CBC has the potential to stand out for cancer treatment, and in this area, CBC could distinguish itself from CBD. These two cannabinoids might share a few similarities when it comes to potential neurological health benefits. CBD has been widely studied for its potential neurological benefits, while CBC is still lacks the research.
Another difference between CBC vs CBD that received attention is cannabichromene’s visible affinity for the nervous system’s TRPV1 receptors. CBD also interacts with the TRPV1 receptor, however, CBC shows an approximately equal affinity for both your TRPV1 and 5-HT1A receptors, which plays a role in neuropathic pain.
Researchers expect CBC to be a more powerful and effective choice over CBD for inflammatory pain. Let’s what future studies show.
Wrapping Up | CBC vs CBD
In discussing CBC vs CBD, both cannabinoids have similarities in potential medicinal benefits. For instance, people in need of better sleep concentrate on hemp products with high concentrations of CBD, or even CBN. In contrast, the people suffering from inflammatory pain often opt for compounds like CBC.
Focusing on a particular cannabinoid doesn’t mean you have to exclude other plant compounds, as there is not a single cannabinoid that isn’t potentially beneficial in some way.
CBC hasn’t been the center of any massive research – yet. However, a few smaller studies have shown this cannabinoid’s medical potential and brought more attention to further research. Scientists are already claiming that focusing on this compound as a significant research area will open otherwise closed doors in the medical and pharmaceutical industry.
The sheer depth of the compounds within the cannabis plant is astounding, and it might be confusing for you – but that’s ok! Continue to read more articles by New Phase Blends to keep up-to-date with information similar to this one on CBC vs CBD.
National Institutes of Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165955/
Royal Society of Chemistry: https://pubs.rsc.org/-/content/articlepdf/2016/np/c6np00074f