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All About Anandamide, the Endocannabinoid of Wonder

Dale blog imageAuthor: Dale Hewett
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To be fair, most people have never heard of anandamide, and also have no clue where it comes from, how it is made, or why it is important for our bodies. What is anandamide? At New Phase Blends, we’re obsessed with all things that have to do with CBD, which is a species of Cannabis. While anandamide isn’t derived from hemp, it does share some distinct similarities with cannabinoids that are found in hemp.

What is Anandamide?

From a technical point of view, anandamide (AEA) is an oxidation mediator acting at the CB1 cannabinoid receptors in our endocannabinoid system.

You’re thinking, “oh cool, that’s awesome! What does that mean?”

Well, you’ve heard of the term ‘cannabinoid’, right?

Anandamide Molecular Structure

In case you haven’t, a cannabinoid is a chemical derived from many different plants, but for the purposes of this discussion, we’ll be talking about cannabis. Phytocannabinoids are plant chemicals derived from cannabis.

Both hemp and marijuana make up the cannabis plant.

Hemp Vs Marijuana Chart

More on Cannabinoids

Anandamide is an endocannabinoid, which means that it is made from within our bodies. This is different from a phytocannabinoid. Our bodies produce anandamide for a variety of different functions. It binds to different cannabinoid receptors, which results in different outcomes.

Other types of phytocannabinoids you’ve likely heard of:

  • cannabidiol (CBD)
  • tetrahydrocannabinol (THC)
  • cannabinol (CBN)

There’s currently over 124 known cannabinoids within the cannabis plant. They all offer many different potential health benefits, depending on some different factors and experimental conditions.

There are two main endocannabinoids:

These two endocannabinoids also can elicit certain health benefits by interacting with different cannabinoid receptors, but instead of getting them from plants, our bodies produce them all on our own.

The role of Anandamide

Several studies suggest anandamide can play a role in having an influence over our memory and brain reward system pathways.

Other studies show it may have also aid in the addiction-producing effects of things like abused drug use. For example, when people who have undergone rehab end up relapsing and using drugs again, well, scientists believe anandamide may play a role in behavior like this.

The effects of anandamide may be enhanced by pharmaceutically controlled metabolism inhibition.

Endocannabinoid System (ECS) Briefly Explained

Anandamide binds to cannabinoid receptors that are known as ‘CB1’. Both the CB1 and CB2 cannabinoid receptor network make up a large network of cells known as the endocannabinoid system.

As you can see in the picture above, there are cannabinoid receptors all over the place. That said, a large potion of them remain in the central nervous system and brain stem.

For those who aren’t already aware, the ECS is a bodily system that is responsible for many different things, but maintaining a bodily homeostasis seems to be this system’s top priority. This system can use both endogenous cannabinoids and phytocannabinoids (like CBD) to accomplish different tasks.

Endocannabinoid System Receptors

How to Increase Anandamide

According to translational psychiatry, “Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide.”

That means by supplementing with CBD products, you can moderately slow down the breakdown of anandamide, which would result in retaining higher anandamide levels.

Many people report massive benefits like pain relief, anxiety reduction, and anti-inflammatory effects after using CBD. This is likely due to how CBD interacts with specific receptors in your body.

Common Questions About Anandamide

Here are some of the more common questions people have on anandamide. Keep in mind that it’s a relatively new discovery, so a lot of the science behind it, and how it works, is under constant revision.

How Does Anandamide Work in Our Bodies?

As we discussed earlier, anandamide works in our bodies via the endocannabinoid system. Current research suggests that anandamide can do things to the human body, like dull pain. When you experience feelings of pain, anandamide interacts with your CB1 cannabinoid receptor and blocks pain signaling. This may be why when people use CBD (which slows the degradation of anandamide) they experience a reduction in pain.

Is anandamide a drug?

No, it is not a drug. It’s a chemical that is made from within our bodies via arachidonic acid in the long chain essential fats. In fact, the cb1 and cb2 receptors can actually be stimulated by endocannabinoids, like anandamide, in a way that makes drug withdrawals more manageable.

Where is anandamide found in the brain?

Anandamide, and other endocannabinoids, are actually released by neurons, then undergo diffusion into astrocytes and neurons, where they are broken down by a fatty acid amide hydrolase, or FAAH.

Related: How Does CBD Affect the Brain
Anandamide Chart
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Fatty acid amide hydrolase (FAAH)

Fatty acid amide hydrolase is an enzyme that is specific to mammals. It aids in breaking down the fatty acid amide family of lipids. These lipids include anandamide, among other things.

Endogenous levels of anandamide are higher in some brain regions, like the brainstem, and parts of the peripheral nervous system.

Some of the more recent studies show us that anandamide is a member of a family of fatty acid chemical compounds.

Summary – Anandamide May Be Part of the Future of Healthcare

It seems that some cannabinoid drugs which, right now, are under clinical trials for the treatment of some psychiatric disorders just may be the future for treatments when it comes to psychiatric disorders.

Since cannabinoids and endocannabinoids both target the same cb receptors (CB1 and CB2), they are both under constant scrutiny for what they can, and cannot do. Cannabinoids from cannabis sativa are not a replacement for anandamide, they just interact in a similar manner with our bodies as anandamide does.

The pharmacological effects and psychoactive effects of anandamide are still being studied by the scientific community. It will take more time, and more peer reviewed research, before the medical community can figure out how best to use endocannabinoids, like anandamide (AEA) or 2-archidonoyl glyerol (2-AG).


Acta Pharmalogica Sinica:
Medical News Today:
Translational Psychiatry:

*FDA disclaimer: none of the statements on this webpage have been approved by the Food and Drug Administration. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Medical advice should be sought before starting any supplement. If you are pregnant or nursing consult with a doctor. Medical advice should be sought if you have any pre-existing medical conditions. If you take other prescription medications, a doctor’s advice should be sought. Site void where prohibited.

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About the Author - CBD Expert Dale Hewett

Dale Hewett is the owner and founder of New Phase Blends. He discovered his passion for CBD use after suffering from injuries sustained while on Active Duty in the US Army. His number one priority is introducing the same CBD products that he himself uses for relief to others who can benefit from them.

Dale holds a Master Degree of Science, and is the inventor of the popular, CBD-based sleep aid known as ‘Sleep.’ He’s given multiple lectures on CBD to institutions such as Cornell’s MBA student program, and Wharton’s School of Business.

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