WHAT IS  10-OXO-DELTA-6A-TETRAHYDROCANNABINOL (OTHC)?

10-oxo-delta-6a-tetrahydrocannabinol (OTHC) is one of the recently discovered cannabinoids. OTHC is related to the THC compound, yet its properties are stated to be different from those of other known compounds. As a well-known compound with therapeutic effects, tetrahydrocannabinol (THC) is still being studied by researchers to explore the distinctive characteristics and functions of other compounds like OTHC in that family.

Cannabinoids were discovered in 1940, with OTHC one of the 130 components of CBD now identified. For over 60 years to date, research has been carried out on the cannabis plant. Ongoing CBD experiments have generated OTHC. Precisely why, where, or how this identification was done is a question we cannot answer.

OTHC is produced though the metamorphosis of acidic cannabinoids. This is the process by which cannabinoids directly neutralize from precursors when heat is applied. The neutralization of CBGV produces THC.

Several important cannabinoids, including THC, CBD, CBC, and CBG, emerge from cannabigerolic acid (CBGA). To produce THC, CBGA first undergoes a reaction that produces a compound known as tetrahydrocannabinolic acid (THCA), the immediate precursor of THC. An enzyme called THCA synthase facilitates this reaction.

OTHC is still unknown in its formation. It is a THC derivative, and that’s all that we know.

The cannabis plant and its compounds should be studied and examined thoroughly. Some of these study efforts have been active amidst the continuing fight for the regulation and use of marijuana.

Although some call for restrictions mostly due to the plant’s ability to cause damage and psychologically impair humans, doctors have been known to actively administer it to patients.

As at the moment, we know little about OTHC apart from its chemical structure. However, because it belongs to the THC family, we believe that its merits and demerits will soon be discovered.

HOW DOES OTHC WORK?

We don’t know exactly how it works. Neither scientists nor chemists know precisely how OTHC functions.

No recent research has been performed to determine if OTHC is a psychoactive substance or whether it has any medicinal effects. Its functions in the medical field are not yet understood and must therefore be looked into.

The need for testing and analysis cannot be a light issue with the cannabis plant on the table for discussion. Testing is what will open the doors to the extent of these compounds’ functions.

POSSIBLE THERAPEUTIC BENEFITS

THC is known for its therapeutic properties. It is used for the treatment of psych activity and conditions like epilepsy.

Although OTHC may seem similar to the mother compounds CBT and THC, we do not know how therapeutic OTHC could be. Medical practitioners have hypothesized the cannabinoid’s value in treating certain medical conditions.

Although the little knowledge we have about the cannabis plant and its compounds is far from being enough, we might as well conclude that OTHC has some advantages of contributing to the sector.

INTERESTING FACTS

  1. The IUPAC name of OTHC is 10-oxo-delta-6a-tetrahydrocannabinol.
  2. The molar mass is 328.4 g/mol.

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REFERENCES

Chan WR, Magnus KE, Watson HA. The structure of cannabitriol. Experientia. 1976;32(3):283-284. doi:10.1007/BF01940792

Prandi, Cristina et al. “Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases.” Molecules (Basel, Switzerland) vol. 23,7 1526. 25 Jun. 2018, doi:10.3390/molecules23071526

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