WHAT IS CANNABITRIOLVARIN (CBTV)?

Cannabitriolvarin (CBTV) is a relatively new cannabinoid, as far as research and discovery is concerned. It is associated with the cannabitriol (CBT) compound and is said to have distinct features from other cannabinoids.

Also similar to tetrahydrocannabinol (THC) in structure, researchers are still trying to identify the distinct features in the chemical composition of CBTV that differentiate it from other CBT compounds, as well as its functions.

Cannabidiols (CBD) were discovered in 1940, and CBTV is just one of over 130 CBD components that scientists have identified so far. The discovery of CBTV is a result of the continuous research being carried out on CBD, by multiple scientists.

We don’t know exactly when, where, or who first discovered the CBTV compound. It is a phytocannabinoid though, produced by plants. This is opposite of an endocannabinoid, which the human body produces.

CBTV is formed through the metamorphosis of acidic cannabinoids. This is the process by which cannabinoids neutralize directly from the precursors when heat is applied to them. Other similiar acidic cannabinoids include:
  • cannabidivarinic acid
  • cannabidiolic acid
  • cannabinolic acid
  • cannabichromevarinic acid
  • cannabigerovarinic acid
  • cannabigerolic acid monomethylether
  • cannabicyclolic acid

CBTV, like the cannabitriol compound, has a chemical composition that includes an additional hydroxyl (OH) substitution resulting in a total of three hydroxyl functional groups.

Extensive research into the cannabis plant and its compounds is still going on. The current war on the legalization of marijuana and its usage has been a block to the advancement of some of this research.

Although some argue for its ban due to its potential to intoxicate and harm users, medical personnel have been openly recommending it for treatments. As of now, we have little to no information about CBTV.

Further, producing sufficient quantities of the compound for testing is problematic as well, as it is not a common cannabiniod. We can only assume that since it belongs to the CBT family, it could have a future as a therapeutic agent.  

HOW DOES CBTV WORK?

Scientists still don’t know exactly how CBTV works. There are no current studies to tell if CBTV is a psychoactive drug or if it will have any therapeutic benefits.

Although some speculate that CBTV could be used in treating epilepsy and brain seizures, there are no conclusive studies that document this. The functions of CBTV in the medical field are yet to be unraveled.

As far as a testing schedule is concerned, CBTV is expected to follow behind CBT, which is following THC. The need for tests and research cannot be understated with the cannabis plant and the cannabinoids it produces.

Only more research will allow us to understand the full extent of the therapeutic benefits of these compounds. 

POSSIBLE THERAPEUTIC BENEFITS

The THC compound is known to have therapeutic features. It is used in seizures treatments and psychoactive purposes. Although CBTV looks quite similar to THC chemically, belonging to the CBT family, we still don’t know the extent to which CBTV can be therapeutic.

Recently some researchers have speculated that CBTV can be used to treat seizures, but without clinical trials and tests, we can’t know this for a fact. 

INTERESTING FACTS

  1. CBTV is formed from the neutralization of CBD through its precursors. It undergoes the process of decarboxylation.
  2. 3H7 are the receptor components of CBTV.
  3. CBTV, like the CBT class, is characterized by an additional hydroxyl (OH) substitution resulting in a total of three hydroxyl functional groups.

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References

The Royal Pharmaceutical Society of Great Britain (30 November 2006). “Cannabis”. In Sean C. Sweetman (ed.). Martindale: The Complete Drug Reference: Single User (35th ed.). Pharmaceutical Press.

Husni, Afeef, “Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2” (2012). Electronic Theses andDissertations. 1459.

Chan WR, Magnus KE, Watson HA. The structure of cannabitriol. Experientia. 1976;32(3):283-284. doi:10.1007/BF01940792

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