Cannabiorcol, or simply CBN-C1, is one of several different cannabinoids within cannabis plants. This derivative of Cannabinol is still somewhat new in regards to research and discovery, however, there’s quite a bit we can learn from it.
What is Cannabiorcol, or CBN-C1?
Cannabidiorcol (CBN-C1) is one of the several derivatives present in the Cannabinol (CBN) family. The CBN family, reportedly, offers a number of medical benefits.
From the (lack of) available volume of research, it is evident that little has been said of Cannabiorcool (CBN-C1). However, inferences can be obtained from the family it belongs to.
Related: The Differences Between CBN and CBD
Whether Cannabiorcool (CBN-C1) is a psychoactive or a non-psychoactive compound is still a bone of contention in the medical field today, as some argue that the compound has no intoxicating properties while some others argue that the compound has an element of psychotropic ability.
Very maturely aged cannabis plants seem to have a higher content of CBN-C1 than younger, less mature plants. This may be evidence of CBG converting into, yet another, cannabinoid we didn’t know about.
Synthesized Version of CBN-C1
In an article published by Nguyen, Jordan, and Kaysar, they mention synthesizing certain cannabis compounds. This is their take on synthesizing CBN-C1:
“This compound was prepared according to the general procedure using CBD-C1 (3c) (Table 5; entry 6.4–c). The product was then purified using flash column chromatography (PE – EE, 95:5 to 9:1). Pale red oil. Rf = 0.33 (PE – EA, 9:1). 1H NMR (CDCl3, 400 MHz) δ 1.54 (6H, s), 2.22 (3H, s) 2.33 (3H, s), 5.02 (1H, s, – OH), 6.21 (1H, s), 6.38 (1H, s), 6.94 – 7.03 (1H, d, J = 7.1 Hz), 7.06 – 7.11 (1H, d, J = 6.7 Hz), 8.09 (1H, s); 13C NMR (CDCl3, 100 MHz) δ 21.4, 28.2, 85.6, 108.1, 110.2, 110.8, 121.1, 127.2, 128.5, 135.3, 138.1, 144.5, 153.3, 154.8. 1H and 13C NMR data agree with those reported in the literature.12 HRMS m/z 255.1372 [M+H]+ . MS/MS [MF1] + 237.1254 13%; [MF2] + 222.1037 100%; [MF3] + 204.0927 64%; [MF4] + 179.0850 63.2%; [MF5] + 169.1000 8.1%; [MF6] + 143.0847 13.0%; [MF7] + 128.0607 10.2%; [MF8] + 105.0705 9.2%; [MF9] + 91.0537 3.2%. (page 8).”
CBN-C1: How Does It Work?
Cannabinol related cannabinoids (CBN) generally interact with CB1 and CB2 receptors. Other cannabinoids have similar binding affinities. It’s this affinity for the CB1 and CB2 receptors that triggers certain bodily affects. This is also why THC derivatives are able to get people high.
It is thought that rather than bind to the receptors like Tetrahydrocannabinol (THC), CBN derivatives act as an agent of physiological change in the human cell. That is, they may play a role of an agonist to the high-threshold thermo-sensors (TRPV2) to aid in delivering health benefits. Again, we simply do not know for sure, though.
Related: What is CBN?
CBN has been shown to contain antibacterial, analgesic as well as anti-inflammatory properties. That said, the sedative properties of CBN (and possibly CBN derivatives) seem to be stronger than other minor effects.
Possible Therapeutic Benefits of CBN-C1
Although research is lacking on this class of cannabinoids, they might show traits of being a curative agent for mental diseases, like Alzheimer’s disease. Other neuro-protective effects might be capable, too.
Cannabiorcol: Interesting Facts
Being part of the CBN and, possibly, the CBND family, it may function as a pharmacological agent to reduce intra-ocular pressure. We simply don’t know for sure.
It’s very hard to make conclusions on a cannabinoid that has little to no scientific studies or data on it.
Appendino, G, et al. “Antibacterial Cannabinoids from Cannabis Sativa: a Structure-Activity Study.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, Aug. 2008,
Vree, T.B., Breimer, D.D., Van Ginneken, C.A.M., Van Rossum, J.M., 1972b. Gas chromatography of cannabis constituents and their synthetic derivatives. Journal of Chromatography 74 (2), 209–224.
Lousberg, R.J.J.C., Bercht, C.A.L., Van Ooyen, R., Spronck, H.J.W., 1977. Cannabinodiol: conclusive identification and synthesis of a new cannabinoid from Cannabis sativa. Phytochemistry 16 (5), 595–597.
Vree, T.B., Breimer, D.D., Van Ginneken, C.A.M., Van Rossum, J.M., 1972b. Gas chromatography of cannabis constituents and their synthetic derivatives. Journal of Chromatography 74 (2), 209–224