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CBG - The Next CBD?

Over time, the reputation of CBD has improved as a universal aid for all sorts of people. Numerous preliminary studies have provided encouraging results which have added and made an increase in the CBG fan base. The majority are unaware of a different cannabinoid (and not a THC) which is of great importance. There are approximately one hundred twenty cannabinoids which are found in cannabis Sativa. One of these cannabinoids is CBG.


In cannabis, over one hundred main cannabinoids are originating from one source. The synthesis of this CBGA with one of the four various dehydrogenase enzyme, CBDA, THCA, CBCA and CBG, during plant growth, in turn, results to CBD, THC, CBC and CBG respectively. This happens without any change after undergoing a decarboxylation process. This decarboxylation process simply means heating them to a specific temperature.


Cannabigerol is one of the many cannabinoids found in cannabis and hemp and stems from CBGA. This CBGA is the acidic form of CBG. Almost all of the CBGA in a plant converts to either THCA and CBDA as cannabis grows. During harvest, the content of CBGA is around 1% or less in most strains. With this, there will, therefore, be a change as the growers are working on forming CBG heavy strains. Research has shown potential advantages associated with CBG. As much as THC/CBD, CBG affects the human body in numerous ways.


To continue, let’s talk about how CBG (one of the cannabinoids ) can make an impact on people before we talk about the potential advantages of this CBG. The body process all cannabinoids; whether it is THC, CBD, CBG, or others via the body’s endocannabinoid system also mimics compounds the body makes naturally. However, there is a clear gap between how each person processes cannabinoids. For example, the THC binds to CB1 receptors which are found in the brain. CBG binds to the CB2 receptor in the gut, the nervous system and the connective tissue. This difference will further be discussed in the effects.


The absence of psychotropic characteristics of CBG is one of the most important things to note about it...consuming it won't intoxicate or get you high. There is a fair limit of conditions the research has shown, suggesting that it can be corrected or wholly erased with cannabigerol. I would hope, by now, many of you are already aware that getting high is not the only thing cannabinoids are useful.


With a small amount of research, science does makes a clear direction in respect to CBG and pain relief. Back in 2010, a study carried out on mouse brain membranes found cannabigerol to act as a potent alpha-2 adrenoceptor agonist. This places it in a top class of drugs known to handle various kinds of pain amongst other things. In 2008, a scientist review brought up a conclusion: the researchers found in 1991 study that CBG is an even more potent analgesic than THC, and this was discussed in the report.


The research carried on the potential role of CBG in fighting against glaucoma dates far back. The Department of Ophthalmology at West Virginia University to looked into this matter in 1990, testing both THC and CBG. They wanted to determine if either cannabinoid would reduce intraocular pressure in cats during their study. To their surprise, when it was administered to their corneas using mini osmotic pumps, they discovered both cannabigerol and its psychoactive counterpart successfully drop intraocular pressure. Since CBG could do this, the researcher concludes that it's a sign that it could be used to treat glaucoma. Obviously, more studies are warranted.


Inflammatory bowel disease is a significant disease affecting people all over the world, and treatments are always needed. While making efforts to investigate how CBG might be able to fight inflammation, the department of Pharmacology at the University of Naples carried out a study on mice. Their study, published in 2013, concluded that CBG reduces murine colitis alongside reducing the nitric oxide production in their macrophages. The researchers suggest that CBG should be considered an experimental inflammatory bowel disease treatment.


Scientists have discovered another fact that link there is a link between CBG and neurodegenerative disease treatment. The Neurotherapeutics Journal, in 2015, published the study on mice suffering from Huntington’s disease found in cannabigerol to protect subjects from several symptoms of illness. This was visibly seen in how it normalized the expression of various genes linked to the disease. It also improved the gene expression of insulin-like growth factor, brain-derived neuropathic factor, and peroxisome proliferator-activated receptor – y. Latest research avenues have been opened, and the path for CBG as a Huntington's treatment is clear.


CBG has a lot of potential benefits, but is it better than CBD? This same question can be asked in another way since these two cannabinoids are entirely different. Nevertheless, research suggests that both have similar reductions in pain, inflammation and glaucoma. Together with CBG seems to be more capable of handling problems like muscle contractions more than other cannabinoids. In all, one is not necessarily better than the other, but your personal preference plays a role.


CBG is fortunately not listed by the UN convention on psychotropic substance, nor bound under Controlled Substances Act in the United States. However, you should, at all times, check your local laws for the most up-to-date information.


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