What Is CANNABIDIOL (CBD) | New Phase Blends


What is Cannabidiol (CBD)?

Cannabidiol (CBD) is a chemical found in the Cannabis sativa plant. Both hemp and marijuana make up the cannabis plant family. More than 124 organic compounds, identified as cannabinoids, have been identified in the cannabis genus. There are several different health benefits for those who use CBD.

Different Cannabis Leaf Structures

Although delta-9-tetrahydrocannabinol (THC) and CBD are presently the most researched cannabinoids, there are also many others that fall within the scope of cannabis. These include cannabinol (CBN)cannabigerol (CBG), cannabidivarin (CBDV), and tetrahydrocannabivarin (THCV) among many others.

In 1940, Roger Adams discovered CBD and successfully extracted it from the cannabis plant. CBD is a major phytocannabinoid in cannabis, accounting for up to 40% of the plant’s total cannabinoid content. Even though THC is the most prevalent active ingredient in marijuana, cannabidiol is also obtained from hemp. Hemp-derived products contain minimal THC amounts, less than 0.3% by dry weight.

Tetrahydrocannabinol and cannabidiol are just two types of cannabinoids found naturally in the resin of marijuana plants, both of which interact with the endocannabinoid receptors that are found throughout mammalian bodies. Several CBD oils can contain both THC and CBD.

There are now many studies concerning CBD that show just how effective it can be. The overwhelming consensus is that CBD is a safe compound, with no serious negative side effects. As such, the licensing of CBD in pharmaceuticals is expected to continue to grow over the next few years.

How Does CBD Work in Our Bodies?

While we don’t understand every facet of how CBD interacts with the body, we do have some knowledge of how it benefits individual systems and conditions. Cannabinoid (CB) receptors are found in numerous areas of the body such as the peripheral and central nervous systems. These systems are responsible for regulating many physiological responses, including chronic pain, memory, appetite, and mood.

While many other cannabinoids have an affinity for binding to the CB1 or CB2 receptors, CBD acts as an inverse agonist and only binds lightly to these receptors. This may explain why CBD helps to block some of the psychoactive effects of THC. 

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Possible Therapeutic Benefits 

Although its exact medical implications are still currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. As reported in research, some of the cannabidiol extracts sold online have possible therapeutic benefits which include, but are not limited to, the following:

Anti-Inflammatory Effects

CBD has been shown in studies to decrease serum levels of pro-inflammatory factors such as interleukin-6 and tumor necrosis factor. CBD also increases levels of interleukin-10, which is an anti-inflammatory cytokine shown to decrease inflammation throughout the body.

In one study rats were given CBD and then injected with an inflammatory substance called carrageenan. After analyzing their bloodwork, they found that CBD produced both anti-hyperalgesia (decreased pain) and anti-inflammatory effects.

Anti-Seizure Effects

Several studies over the past two decades have reported that CBD demonstrates anti-seizure activity. While the mechanism of action isn’t fully known, there are a few different methods by which CBD is assumed to provide its anti-seizure activity.

Some of these include targeting abnormal sodium and calcium channels, reduction of tumor necrosis factor, antagonist action of the GPR55 receptor, and modulation of adenosine receptors. Regardless of which mechanism of action is responsible, there is clear evidence supporting the use of CBD for seizures.

Anti-Anxiety Effects

Recent studies show that CBD is an effective treatment option for reducing anxiety, panic disorder, social anxiety, OCD, and PTSD. CBD has even been shown to reduce anxiety induced by public speaking. When CBD is taken alongside THC it helps to reduce any anxiety or psychosis-like effects from THC.

One possible mechanism of action that may be responsible for CBD’s anti-anxiety effects is its antagonism of the 5-HT1a receptor. This receptor is heavily involved in both anxiety and depression. Although research is still developing on how CBD promotes anti-anxiety effects, there are plenty of studies showing just how effective it can be.

Anti-Tumor Effects

There are positive emerging studies on the use of CBD in treating malignant tumors. CBD has anticancer effects on both in-vivo cell lines and in-vitro animal subjects. The main methods by which it may prevent cancerous activity are:

  • inhibiting cancer cell migration and adhesion
  • anti-proliferative effects (preventing the spread of cancer cells) 
  • pro-apoptotic effects (promoting cancer cell death)
  • anti-invasive effects

In addition to the positive benefits above, it has also been shown to protect against the negative effects of chemotherapy. CBD shows great potential in blocking each phase of tumor progression.

I want to be clear here, in that CBD does not cure cancer. There are simply studies being conducted for the use of CBD in cancer treatment regimens.

Neuropathic Pain Benefits

One of the most popular reasons for using CBD is to treat nerve pain. Even a topical application of CBD oil to the skin was found to be an effective treatment for neuropathic pain. CBD has been shown to block pain transmission, activate pathways that lead to the reduction of pain, and also modify the emotional component of pain.

Cbd And Nerve Response

These effects are thought to be induced by its light interactions with receptors in the dorsal root ganglia and spinal cord dorsal horn. Chronic pain is also decreased due to CBDs modulation of the body’s immune response, which leads to reduced neuronal sensitization and lower levels of chronic pain.

Other Emerging Benefits

CBD has also shown promise for other conditions such as:

Research is still ongoing, and we expect this list to continue to expand as more studies are performed.

Interesting Facts About CBD

1. Taking CBD with a meal that is rich in fat increases the amount of CBD that is then absorbed by the body. This is liable to increase the effects of CBD.

2. Taking CBD may result in drowsiness or sleepiness. Using it along with other herbs and supplements with these same effects might cause too much drowsiness.

3. The Food and Drug Administration (FDA) approved Epidiolex as a prescription drug which uses CBD. Other FDA approved drugs should be coming soon. That said, the FDA still hasn’t approved CBD for use as a dietary supplement.

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